Environmental factors are the main cause of chronic diseases, genetic factors are insignificant

Editor's note: With the development of science and technology, people's research on genes is also further developed. Martin Smith, a toxicologist at the University of California, Berkeley, said: "In the past, we overemphasized the relationship between genetic factors and diseases, and Compared with environmental factors, genetic factors seem insignificant. "Venice ’s contact group study has revealed some gene expression markers, such as people suffering from leukemia and exposure to heavy metals and other toxic chemicals.

In genome-wide related research, scientists searched for genetic variants related to disease, which failed to fully explain why some people are more prone to chronic diseases than others, such as type 2 diabetes. According to the "Nature" website reported on November 27, this week, two projects said they had obtained a total of 17.3 million euros (22.4 million US dollars) from the European Commission to study the "contact group"-the impact of environmental factors on health. They will track the daily exposure of thousands of people using smartphones to reveal the biological triggers of diseases from environmental factors.

The researchers hope that the four-year study will benefit public health. At present, genomic research has not yet achieved this goal. Martin Smith, a toxicologist at the University of California, Berkeley, said: "In the past, we overemphasized the relationship between genetic factors and disease, and compared with environmental factors, genetic factors seem insignificant." He participated in the new 8.7 million euros Contact group items.

This research project was led by Paul Venice, an environmental epidemiologist at Imperial College London. The subjects will carry smartphones equipped with sensors to measure daily chemical exposure and monitor molecular changes through blood testing. Most participants also participated in another long-term health study. The goal is to look for differences in biomarkers between people living in air-polluted areas and people who are exposed to urban smoke every day to understand the triggering conditions for diseases such as heart disease, asthma and lung cancer.

The Venice contact group study has revealed some gene expression markers, such as people suffering from leukemia and exposure to heavy metals and other toxic chemicals.

Another 8.6 million euro human early contact group project will focus on children and pregnant women. Martina, an epidemiologist at the Environmental Epidemiology Research Center in Barcelona, ​​Spain, who leads the project, said that children are smaller and all organs are developing, so they are more susceptible to environmental influences. The researchers will track the biomarkers of the disease to evaluate the effects of environmental factors on development, obesity, immune development and asthma. Both projects will generate large amounts of data, and these data resources will be freely shared with other researchers.

The interest of the contact group in the United States is also increasing. Although it has not yet invested as much as any project in Europe, this year, the National Research Council of the United States requested more funding for contact group research, and the National Institute of Environmental Health Sciences plans to include it as a priority.

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