Tianjin Medical University authoritative journal reveals the mechanism of cancer metastasis regulation
Researchers from the Cancer Hospital of Tianjin Medical University confirmed in a new study that Succinate dehydrogenase 5 (SDH5) regulates (GSK) -3β-β-mediated lung cancer metastasis. The research findings were published online in the August 27th Journal of Biochemical Chemistry (JBC). The corresponding author of the paper is Professor Changli Wang of Tianjin Medical University Cancer Hospital. He has been engaged in clinical surgery of chest tumors for a long time, mainly engaged in early diagnosis, surgical treatment, comprehensive treatment of lung cancer and basic research and clinical research related to lung cancer. Published more than 50 papers in important journals at home and abroad. Lung cancer is the most common type of cancer in the world and a major cause of cancer deaths among men and women in China. Lung cancer is usually a treatable disease without metastasis. Therefore, early diagnosis of patients with lung cancer metastasis can reduce the morbidity and mortality of the disease. Cancer cells invade and metastasize from the primary tumor to surrounding tissues, resulting in the formation of metastases. In order to obtain such invasive ability, cancer cells must acquire some unique phenotypic changes such as epithelial-mesenchymal transition (EMT). EMT is a process characterized by loss of cell adhesion, suppression of E-cadherin expression, and increased cell motility. EMT, a highly conservative cellular process, can transform polarized, usually immobile epithelial cells into active, interstitial-like cells. This process was first identified as a feature of embryogenesis, and in recent years it has been shown to participate in promoting cancer invasion and metastasis. Decreased expression of E-cadherin or increased expression of vimentin are closely related to various lung cancer progress indicators including grade, local invasion, blood channel spread, and tumor recurrence after radiotherapy. SDH5 is a necessary condition for succinate dehydrogenase covalent binding (flavination). SDH5 is associated with an increased risk of several types of cancer. SDH5 mutations are found in paraganglioma and gastrointestinal stromal tumors (GISTs). SDH5 is down-regulated in various types of human cancer, and it plays an important role in tumor formation. Therefore, SDH5 may play a tumor suppressor role in cancer formation. However, its role and mechanism in lung cancer metastasis are not yet clear. In this article, the researchers confirmed that in lung cancer cell lines and clinical lung cancer samples, the loss of SDH5 expression caused E-cadherin inhibition, upregulation of vimentin, and initiation of epithelial-mesenchymal transition. In SDH5 knockout mice, lung epithelial cells showed increased interstitial markers characteristic of EMT. Using a mouse model of human heterologous metastasis, the researchers observed that endogenous SDH5 inhibition in human cancer cells can lead to the formation of multiple lymph node metastases. Moreover, the research data indicate that SDH5 plays an important role in regulating EMT through regulating (GSK) -3β-β-catenin signaling pathway. These results reveal the important role of SDH5 in EMT, indicating that SDH5 may be a prognostic biomarker and potential therapeutic target for lung cancer metastasis. Frank Green Coffee Cup,Coffee Cups With Lids,Best Reusable Coffee Cup,Travel Coffee Cup Shantou Oudaya Packaging Co. Ltd. , https://www.imloudaya.com