Southern Medical University discovers "double-sided" protein associated with Chinese gastric cancer
Recently, a group led by Professor Zhou Jianwei of the Cancer Center of Nanjing Medical University, after analyzing samples of 1,806 gastric cancer patients, found that the indicators of the two proteins in the human body can be used to judge the postoperative survival status of gastric cancer patients in the Chinese population and can predict chemotherapy effect. This result has been published in the Journal of Clinical Cancer Research of the American Cancer Research Association. According to reports, these two proteins are named JWA and XRCC1. Dr. Wang Shouyu, who participated in the project, introduced that DNA molecule is the basis of genetic material. Once it is damaged and cannot be repaired in time and effectively, the damage will be pathogenic when accumulated to a certain extent. However, there are also DNA damage repair systems in living organisms, among which "repairmen" such as JWA and XRCC1 play a vital role. "So, in healthy people, if the expression of JWA and other proteins is high, it means that this person is not easy to get cancer." After comparing the cancer tissues and normal tissues of more than 1,800 gastric cancer patients, the researchers concluded that people with high expression of JWA and XRCC1 in gastric cancer tissues survive longer after surgery, and these two proteins can be used as new indicators. To determine the possible survival of gastric cancer patients after surgery. Moreover, "the sensitivity and accuracy of the new indicators are higher." The researchers introduced that the detection method is not complicated, and the removed tumor tissue can be detected, and the level of protein expression can be determined according to the depth of staining. Able to detect, the one-time cost is about 80 yuan. However, the study found that in patients with gastric cancer undergoing adjuvant chemotherapy, if these two proteins are detected in gastric cancer tissues with high expression, then the chemotherapy does not benefit the patient too much; and patients with low expression of these two proteins have good chemotherapy effects. "The significance of this study is not only to focus on the indicators that predict the prognosis of patients, we will also increase the research on other biomarkers in the next step, and hope to develop a targeted drug." Zhou Jianwei said: "For example, directly targeting the JWA in the organization For cancer patients with low expression, use platinum-based adjuvant chemotherapy drugs in a timely manner; or use this drug to increase their JWA expression level to directly inhibit the development of tumors. Both methods may improve the treatment effect. "At present, he is working on Carrying out this research is expected to achieve results in the near future.
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