Danish scientists wait for humans to test AIDS or usher in the dawn

Editor's note: From the first human discovery of AIDS (HIV) in 1981 to the present, from the awareness of the disease to the fear, because of its incurability, extremely high mortality rate and infection risk, let everyone talk about Ayse. For more than 30 years, scientists in the medical field around the world have hoped that they have been studying the disease and experimenting with treatment methods. Recently, news came from Denmark that scientists in the country may have found a new cure for AIDS on a large scale, and the stubborn disease may be attacked in the near future.

According to relevant literature, AIDS, Acquired Immunodeficiency Syndrome (or Acquired Immunodeficiency Syndrome, English: Acquired immunodeficiency syndrome, AIDS, transliterated as AIDS), is a reversal of the human immunodeficiency virus (HIV) After recording the virus infection, due to the destruction of the immune system, it has gradually become the target of many opportunistic diseases, contributing to a variety of clinical symptoms, collectively known as syndrome.

On June 5, 1981, the US Centers for Disease Control and Prevention notified the world ’s first case of HIV infection, and since then humans have waged a long fight against this number one infectious disease. In the early days of AIDS, the medical community did not know much about the disease, and there was no cure for it. The infected people had to suffer from torture to death. Until the dawn of the end of 1995, the invention and wide application of cocktail therapy delayed the time of onset of most infected people, and the mortality rate began to decline significantly. As of the 21st century, scientists are still carrying out a large number of research and clinical experiments, in order to find a way to cure the disease as soon as possible.

Recently, several scientists from Aarhus University Hospital in Denmark issued a public statement, saying that it is very possible to find a new treatment for AIDS on a large scale. In the new therapy, they separated the HIV virus attached to the DNA, made it float to the cell surface, and reached the "jurisdiction" of the body's natural immune system. At this time, the body's immune system was stimulated by vaccine injection. The viruses are killed together.

In layman's terms, the new therapy is to "catch" HIV from human cells to reach the cell surface. Once the virus reaches the cell surface, the body's natural immune system can kill the virus when it is stimulated by the "vaccine". The laboratory experiment phase of the therapy has been successful, which fully proves the feasibility of the new therapy. This therapy uses histone deacetylase activity inhibitors, which are more commonly used in the treatment of cancer, to drive HIV out of patients' DNA. Researchers are using Pabitastat, an inhibitor of histone deacetylase activity that is particularly powerful.

A few days ago, the new therapy is already in the clinical trial stage. Several scientists in Denmark are very much looking forward to the results of the trial, saying that once the trial is successful, humans are expected to achieve the goal of low-cost, large-scale cure of AIDS. There are currently 15 patients participating in clinical trials. If the results of the experiment are not bad, more patients will continue to participate.

Dr. Ole Sergau, a senior researcher at Aarhus University Hospital in Denmark, said that I can almost certainly say that we will successfully release the HIV repository. The challenge is to get the patient's immune system to recognize and eliminate the virus. It depends on the strength and sensitivity of each patient's immune system. Dr. Seco emphasized that their treatments are different from preventive vaccines, and their awareness of unsafe behaviors, including unprotected sex and sharing needles, is still the most important to fight against HIV.

Another way is the research on AIDS vaccines, in the hope that during the defense period, the body will be able to generate protests and hinder the risk of infection. Significant progress has been made in the research on AIDS vaccine chaired by Professor Zhang Linqi of Tsinghua University School of Medicine. The team for the first time in the world has achieved an innovative AIDS vaccine strategy that combines the use of replicating vaccinia virus vectors and mucosal pathways for the first time to immunize, laying the foundation for further optimization of the vaccine and human trials. At present, this research has received continuous support from the “12th Five-Year Plan” major special project, and human clinical research will be carried out in the next 5 years.

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